Neuronal survival

Every compound in the sci-wiki that affects neuronal survival; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

2 sourced · 0 reference

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Nootropic

DNSP-11

DNSP-11 is a synthetic 11-amino-acid peptide copied from the pro-region of GDNF, a natural protein that helps dopamine-producing brain cells survive. In rats and in a small group of monkeys it raised dopamine activity and protected dopamine neurons against chemical damage, which is why it is discussed as a possible Parkinson's disease treatment. The evidence is entirely animal and cell-culture work, almost all of it from a single laboratory at the University of Kentucky; no person has ever received it in a registered clinical trial, and the receptor it acts on has never been identified. Material sold online under this name is an unapproved research chemical with no human safety data behind it.

1 outlet

Nootropic

EPObis

EPObis is a synthetic dendrimeric peptide designed from the binding Site 1 sequence of human erythropoietin, guided by the crystal structure of the erythropoietin-receptor complex. It binds the erythropoietin receptor and reproduces the cytokine's tissue-protective signaling; in cultured neurons it promotes neurite outgrowth and survival in a receptor-dependent manner. Unlike erythropoietin itself, EPObis is non-erythropoietic, so it activates protective pathways without stimulating red blood cell production, and after systemic administration it crosses the blood-brain barrier into the cerebrospinal fluid. In rodent studies it reduces tumor necrosis factor release from activated macrophages and microglia, delays clinical signs in experimental autoimmune encephalomyelitis, and enhances working memory, marking it as an experimental neuroprotective and anti-inflammatory research peptide.

2 outlets