Motivation

Every compound in the sci-wiki that affects motivation; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Dopaminergic

Amfonelic Acid

Amfonelic acid (AFA, WIN 25978) is a synthetic 1,8-naphthyridine carboxylic acid structurally derived from the antibacterial scaffold of nalidixic acid, and it functions as a potent and highly selective dopamine reuptake inhibitor with minimal action on the norepinephrine or serotonin transporters [1][2]. Unlike amphetamine, which reverses the dopamine transporter to force efflux, amfonelic acid raises extracellular dopamine by blocking reuptake, and it has been used experimentally as a pharmacological probe of dopamine transporter function and vesicular dopamine storage [1]. It is a long-acting central stimulant and is sold today only as a research chemical, not as an approved medicine [3].

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Nootropic

Centanafadine

A once-daily reuptake inhibitor of norepinephrine, dopamine and serotonin, approved July 2026 for ADHD in adults and children aged 6 and older.

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Nootropic

MRZ-9547

MRZ-9547 is the R-enantiomer of phenylpiracetam (R-fonturacetam), developed by Merz Pharmaceuticals as a selective dopamine transporter (DAT) inhibitor for the fatigue and reduced motivation of Parkinson's disease [1][2]. In rats it dose-dependently increases effort-related responding and reverses motor deficits in Parkinson models, moderately raising striatal dopamine release, while its L-enantiomer MRZ-9546 is far less active [1][2]. It should not be conflated with racemic phenylpiracetam: MRZ-9547 is a single, defined enantiomer studied specifically as a DAT-based anti-fatigue agent [2].

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