Longevity

Every compound in the sci-wiki that affects longevity; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Peptide

ACE-167

ACE-167 is an orally available synthetic tetrapeptide under preclinical development by Acesis BioMed as a non-steroidal approach to stimulating the body's own testosterone production, primarily for male hypogonadism and related conditions [company disclosures]. Rather than acting on the central nervous system, it works at the mitochondrial level within testicular Leydig cells to promote endogenous steroidogenesis. Independent peer-reviewed literature on ACE-167 is currently absent, so its profile rests on company and industry-database sources and should be regarded as preliminary.

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Bioregulator

Goralatide

Goralatide is the drug name for Ac-SDKP (N-acetyl-Ser-Asp-Lys-Pro), an endogenous acetylated tetrapeptide the body makes by trimming the N-terminus of thymosin beta-4. It has two jobs research cares about: it holds blood-forming stem cells in a resting state (which shielded them during chemo in early trials), and it acts as a natural brake on tissue fibrosis and inflammation.

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Neuropeptide

HNG (S14G-Humanin)

HNG is a synthetic potency-boosted analog of humanin, a 24-amino-acid peptide encoded within mitochondrial DNA. Swapping one residue (serine to glycine at position 14) makes it roughly a thousand times more cytoprotective than natural humanin in cell assays, which is why almost all animal work on the humanin pathway uses HNG rather than the wild-type peptide. It is studied for protecting neurons against amyloid-beta and ischemic insults, and for metabolic and insulin-sensitizing effects.

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