Integrated stress response

Every compound in the sci-wiki that affects integrated stress response; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Neuroprotection

Fosigotifator

Fosigotifator (ABBV-CLS-7262) is an orally bioavailable small-molecule activator of eukaryotic translation initiation factor 2B (eIF2B) developed jointly by AbbVie and Calico Life Sciences [1]. By stabilizing and activating eIF2B, it attenuates the integrated stress response (ISR), a conserved pathway that suppresses global protein synthesis under cellular stress, positioning the compound as a candidate neuroprotective agent that advanced into human trials for amyotrophic lateral sclerosis (ALS) [1][2].

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Nootropic

IFB-088

IFB-088 (also called icergustat, related to the tool compound Sephin1) is an experimental small molecule that inhibits the regulatory subunit of protein phosphatase 1 known as PPP1R15A (GADD34). By blocking this subunit it prolongs the cell's integrated stress response, and it has been studied for neurodegenerative and demyelinating conditions such as certain peripheral neuropathies. It is an investigational compound, not an approved drug.

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