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Guanfacine is a non-stimulant ADHD medication and a selective alpha-2A adrenergic receptor agonist, sold as extended-release Intuniv for ADHD and immediate-release Tenex for high blood pressure. It has no dopaminergic reward action and no abuse potential, but it lowers blood pressure and heart rate and must never be stopped abruptly because of rebound hypertension.
A once-daily reuptake inhibitor of norepinephrine, dopamine and serotonin, approved July 2026 for ADHD in adults and children aged 6 and older.