Hormone balance

Every compound in the sci-wiki that affects hormone balance; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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SERM

4-Hydroxytamoxifen

4-Hydroxytamoxifen (afimoxifene, 4-OHT) is the potent active metabolite of tamoxifen and one of the most powerful selective estrogen receptor modulators available, binding the estrogen receptor with far greater affinity than tamoxifen itself. Prized across clinical research and hormonal management, it shuts down estrogen signaling in breast tissue while behaving tissue-selectively elsewhere. It is also a cornerstone laboratory reagent, valued for switching on tamoxifen-inducible genetic systems with precision.

1 outlet

SERM

Endoxifen

Endoxifen is the most potent active metabolite of the breast cancer drug tamoxifen, a powerful antiestrogen that does much of tamoxifen's real work inside the body [1]. Because the body relies on the enzyme CYP2D6 to make it, blood endoxifen levels vary widely between people and strongly predict how well tamoxifen works, which has driven efforts to monitor levels and to give endoxifen directly as a drug [2][3]. For precision in estrogen-driven disease, endoxifen is a compound of intense and growing clinical interest.

1 outlet