HDAC (class I)

Every compound in the sci-wiki that affects hdac (class i); the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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HDAC Inhibitor

Entinostat

Entinostat is an oral, class I-selective HDAC inhibitor built on a benzamide scaffold; "class I-selective" means it preferentially hits HDAC1, HDAC2, and HDAC3 rather than the whole HDAC family. It has been studied mostly in breast cancer, usually paired with hormonal (anti-estrogen) therapy to try to overcome treatment resistance, and it drew a lot of interest in immuno-oncology because blocking these enzymes can dial down the immune-suppressing cells that let tumors hide. It is an investigational drug; despite encouraging mid-stage results, its big confirmatory breast-cancer trial did not deliver, so it has never reached routine approval.

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HDAC Inhibitor

Romidepsin

Romidepsin is an unusual HDAC inhibitor; instead of the small hydroxamate or benzamide chemistry of most drugs in this class, it is a bicyclic depsipeptide (a ring-shaped molecule made of both amino acids and an ester link) originally isolated from a soil bacterium. It behaves as a prodrug that only becomes active once inside the cell, and it prefers the class I HDACs. It was approved to treat T-cell lymphomas of the skin and, later, the lymph nodes and other tissues, though its use in the second setting has since narrowed after a confirmatory trial disappointed.

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