Extracellular matrix

Every compound in the sci-wiki that affects extracellular matrix; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

2 sourced · 1 reference

←extracellular matrix3/3

Peptide

B7-33

B7-33 is a single-chain peptide derived from the B-chain of human relaxin-2 (H2 relaxin), engineered as a functionally selective agonist of the relaxin receptor RXFP1. It reproduces relaxin's potent anti-fibrotic and vasodilatory actions while biasing signaling toward the tissue-protective ERK pathway rather than the cAMP signaling linked to relaxin's tumor-promoting risk [1]. In multiple preclinical models of heart and lung disease it prevented or reversed organ fibrosis with a potency similar to full relaxin, positioning it as a promising anti-fibrotic peptide [1].

2 outlets

Peptide

Matrixyl

Matrixyl is a trade name for a family of synthetic cosmetic peptides used in anti-aging skincare, the original being palmitoyl pentapeptide-4 (also written pal-KTTKS), a short chain of amino acids attached to a fatty acid. These peptides are designed as matrikines, signal fragments that mimic pieces of broken-down collagen and prompt skin cells to make new collagen and other matrix proteins [1][2]. Marketed as a topical ingredient, palmitoyl pentapeptide has been reported in a controlled study to reduce the appearance of fine lines and wrinkles [1].

1 outlet

reference shelf; no outlet carries these yet

Peptide

Palmitoyl Hexapeptide-12

Palmitoyl Hexapeptide-12 is a synthetic cosmetic peptide; a short six-amino-acid chain with a palmitic acid (a fatty acid) tail attached so it sits better in the skin's lipid layers. It is used topically in anti-aging and conditioning skincare, marketed to support the look of firmness and smoothness. This is a cosmetic ingredient, not a drug, and the systemic (whole-body) evidence for it is limited.

reference