Executive Function

Every compound in the sci-wiki that affects executive function; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Nootropic

Org 26576

Org 26576 is an investigational ampakine from the Organon (later Merck) program; a positive allosteric modulator of AMPA-type glutamate receptors that enhances hippocampal AMPA responses in an exposure-dependent way. Unusually for the class it reached multiple human trials in mood and attention disorders, where it produced signals of improved executive function and processing speed alongside a distinctive neuroendocrine profile of raised growth hormone and lowered cortisol.

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Nootropic

SAGE-718

Dalzanemdor (SAGE-718) is a first-in-class, orally administered synthetic neuroactive steroid developed by Sage Therapeutics that acts as a positive allosteric modulator (a molecule that boosts a receptor's response without occupying its main agonist site) of the N-methyl-D-aspartate (NMDA) receptor, the principal excitatory glutamate-gated ion channel of the brain. It is a structural analog of the endogenous brain oxysterol 24(S)-hydroxycholesterol (24(S)-HC), a cholesterol metabolite that the same laboratory identified as a naturally occurring NMDA receptor PAM. The compound was advanced into clinical development for cognitive impairment associated with disorders thought to involve NMDA receptor hypofunction, including Huntington's disease, Parkinson's disease, and Alzheimer's disease. Its Phase 2 program, most notably the DIMENSION study in Huntington's disease, largely failed to meet primary cognitive endpoints during 2024 and 2025, after which Sage Therapeutics terminated the open-label Phase 3 PURVIEW study.

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