dihydrofolate reductase

Every compound in the sci-wiki that affects dihydrofolate reductase; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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←dihydrofolate reductase2/2

Antineoplastic

Methotrexate

Methotrexate is an antimetabolite drug of the antifolate class used both as a cancer chemotherapy agent and, in much lower doses, as an immune-modulating treatment for autoimmune disease. By interfering with the body's use of folate, it blocks the synthesis of DNA and slows the growth of rapidly dividing cells, which underlies its use against several cancers. At low weekly doses it is a first-line disease-modifying drug for rheumatoid arthritis and is also used in psoriasis, other autoimmune conditions, and to end ectopic and molar pregnancies.

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Blend

Sulfamethoxazole + Trimethoprim

Sulfamethoxazole and trimethoprim, given together as a fixed-dose combination known as co-trimoxazole, is a widely used antibiotic. The two drugs block successive steps in the pathway bacteria use to make folate, producing a synergistic effect stronger than either alone. It treats infections including urinary tract infections, certain respiratory and skin infections, and is a first-line agent for Pneumocystis pneumonia in people with weakened immune systems.

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