cholesterol synthesis

Every compound in the sci-wiki that affects cholesterol synthesis; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Cardiovascular

Bempedoic Acid

Bempedoic acid is an oral cholesterol-lowering drug and the first of a class that inhibits the enzyme ATP-citrate lyase, sold under brand names such as Nexletol and Nilemdo. It reduces LDL cholesterol by curbing cholesterol production in the liver, and because it is activated only in the liver and not in muscle, it tends to cause fewer muscle complaints than statins, which makes it useful for people who cannot tolerate statins. A large outcomes trial showed it lowers the risk of cardiovascular events, and it is also sold combined with ezetimibe.

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Blend

Bempedoic Acid + Ezetimibe

Bempedoic acid plus ezetimibe is a fixed-dose combination tablet that pairs two non-statin cholesterol-lowering drugs, marketed as Nexlizet in the United States and Nustendi in Europe. Bempedoic acid curbs the liver's production of cholesterol while ezetimibe blocks cholesterol absorption in the gut, so together they lower LDL cholesterol more than either does alone. The combination is used for people who need additional LDL reduction, particularly those who cannot tolerate statins or have not reached their targets on them.

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