Central nervous system: nootropics and compounds | sci-wiki

Dermorphin

Dermorphin is a naturally occurring opioid peptide, a chain of seven amino acids first isolated from the skin of South American frogs of the genus Phyllomedusa. It is among the most potent and selective mu-opioid agonists known, reported to be many times stronger than morphine, and it is one of very few peptides made by a vertebrate to contain a D-amino acid, a D-alanine residue installed by post-translational epimerization that is essential to its potency and its resistance to protease breakdown. Dermorphin is not an approved medicine; it is used in research and is known for its illicit use as a doping agent in horse racing.

1 outlet

Hormone

6-Ketoprogesterone

6-Ketoprogesterone (systematic name pregn-4-ene-3,6,20-trione) is a synthetic oxidised derivative and minor oxidative metabolite of progesterone in which an additional ketone (a carbonyl group) is introduced at the sixth carbon of the steroid B-ring. First isolated from perfused human placentae in 1956 and characterised pharmacologically in Japan in 1958, it is notable for having lost the classical progestational activity of its parent hormone while retaining a weaker, progesterone-like depressant action on the central nervous system. Today it exists chiefly as a pharmacopeial reference standard (a purified compound used to calibrate analytical assays), as a mechanistic probe for the C6 oxidation of progesterone, and as a metabolic curiosity of pregnancy endocrinology. Its status as a genuinely endogenous neurosteroid remains uncertain, so it is treated conservatively as non-endogenous.

reference

Antineoplastic

Acivicin

Acivicin is a natural glutamine antagonist, originally isolated from Streptomyces sviceus, that was investigated as an antineoplastic (anticancer) agent for its ability to irreversibly block glutamine-dependent enzymes.

reference

Modulators

AUT-00063

AUT-00063 is an investigational Kv3 (Shaw-family) potassium channel modulator developed by Autifony Therapeutics for hearing disorders, chiefly tinnitus and age-related hearing loss.

reference

Opioid

Axomadol

Axomadol (EN3324) is an investigational centrally acting analgesic that combines opioid receptor agonism with inhibition of noradrenaline, and to a lesser degree serotonin, reuptake.

reference