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Every compound in the sci-wiki that affects cell division; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.
0 sourced · 3 reference
An investigational antineoplastic (chemotherapy) agent that was never marketed. It is the L-alanine ester of estramustine, combining a nitrogen mustard alkylating fragment (normustine) with the estrogen estradiol via a carbamate linkage.
An orally available, ATP-competitive small-molecule inhibitor of Aurora A kinase, an enzyme that regulates cell division. Developed by Takeda and later licensed to Puma Biotechnology, it was investigated across multiple cancer types including peripheral T-cell lymphoma, neuroendocrine prostate cancer, and acute myeloid leukemia.
Atrimustine is an investigational cytostatic antineoplastic agent developed in Japan, structurally an estradiol molecule conjugated to the nitrogen mustard chlorambucil. It was studied for breast cancer, non-Hodgkin lymphoma, and prevention of graft-versus-host disease after bone marrow transplant, but never reached full marketing approval.