Cardiac function

Every compound in the sci-wiki that affects cardiac function; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Peptide

Hexarelin

Hexarelin (examorelin) is a synthetic hexapeptide growth hormone secretagogue that binds the ghrelin receptor (GHS-R1a) to trigger a potent, reproducible, and largely somatostatin-resistant pulse of endogenous growth hormone, an effect that is strongest in pubertal children and young adults and blunted in the very young and elderly. What distinguishes it from other secretagogues is a second receptor: hexarelin binds the cardiac scavenger receptor CD36, through which it exerts growth-hormone-independent cardiovascular actions, including protection against ischemia-reperfusion injury, attenuation of post-infarction heart failure via PTEN and Akt/mTOR modulation, and CD36-PPAR-gamma signaling relevant to lipid and energy metabolism. Some growth hormone secretagogues, including hexarelin, additionally show angiotensin-converting-enzyme-inhibiting activity that may contribute to their vascular effects. As a result it is one of the most thoroughly characterized peptides in its class, studied both as a growth hormone provocative agent and as an experimental cardioprotective compound.

3 outlets

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Cardiovascular

S107

S107, also called ARM036, is a member of the Rycal class of small molecules that stabilize ryanodine receptors (RyR), the calcium release channels of the sarcoplasmic and endoplasmic reticulum. By preserving the binding of the stabilizing subunit calstabin to leaky RyR channels, S107 reduces pathological intracellular calcium leak implicated in heart failure and arrhythmia [1][2], muscle fatigue and reduced exercise capacity [3], muscular dystrophy [4], and stress-related cognitive dysfunction [5].

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