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Every compound in the sci-wiki that affects bowel motility; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.
0 sourced · 2 reference
Asimadoline is an orally active, peripherally restricted kappa-opioid receptor agonist that was investigated for irritable bowel syndrome (IBS), mainly the diarrhea-predominant subtype, and for other conditions involving visceral pain.
A Takeda M1 positive allosteric modulator aimed at constipation rather than cognition; it amplifies the enteric nervous system's own acetylcholine signaling to produce coordinated, propagating colonic contractions.