Bone Growth

Every compound in the sci-wiki that affects bone growth; the ones you can source are floated to the front, then the reference-only entries. Tap any for the full entry, mechanism, and outlets.

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Bone

Tyra-300

Tyra-300 is an investigational oral drug (from Tyra Biosciences) that selectively blocks FGFR3, one member of the fibroblast growth factor receptor family. It is being studied in two very different settings: bladder (urothelial) cancers driven by FGFR3 changes, and achondroplasia (a common form of dwarfism), where an overactive FGFR3 stunts bone growth. Its selling point is precision; it aims to hit FGFR3 while leaving the related FGFR1, FGFR2, and FGFR4 mostly alone. It is still in clinical trials and not an approved medicine.

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Peptide

Vosoritide

Vosoritide (brand name Voxzogo) is a lab-made version of C-type natriuretic peptide (CNP, a natural molecule that helps regulate bone growth). It is approved to help children with achondroplasia (the most common form of dwarfism) grow taller by targeting the overactive growth signal behind the condition. It works as a counter-signal to FGFR3, the receptor that, when overactive, holds back the growth plates in the long bones.

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