bacterial DNA gyrase/topoisomerase

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Antibiotic

Levofloxacin

Levofloxacin is a broad-spectrum antibiotic in the fluoroquinolone class, used to treat bacterial infections such as pneumonia, sinusitis, and urinary tract infections. Chemically it is the more active mirror-image half of an older drug, ofloxacin. It is sold under brand names including Levaquin and, because of serious safety concerns, is now generally reserved for infections where other options are unsuitable.

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Antibiotic

Moxifloxacin

Moxifloxacin is a broad-spectrum antibiotic of the fluoroquinolone class, active against many Gram-positive and Gram-negative bacteria. It kills bacteria by interfering with the enzymes they use to copy and package their DNA, and it is used for infections such as pneumonia, sinusitis, certain skin and abdominal infections and bacterial eye infections. Approved in the United States in 1999 under the brand name Avelox, it is effective but, like other fluoroquinolones, carries warnings about uncommon but serious effects on tendons, nerves and heart rhythm.

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