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for educational and safety purposes
class, effects, and the receptor fingerprint, side by side; add up to four, then source the whole stack
Popular head-to-heads →GABA-A receptor (synaptic, gamma2-containing)positive allosteric modulator of phasic inhibition
GABA-A receptor (extrasynaptic, delta subunit)positive allosteric modulator of tonic inhibition; a deliberately optimised analog of allopregnanolone
Extrasynaptic delta-subunit GABA-A receptorPositive allosteric modulation and direct gating at higher concentrations, enhancing tonic inhibitory current
Synaptic gamma2-subunit GABA-A receptorPositive allosteric modulation of GABA-evoked phasic currents
Neurosteroid transmembrane binding site on GABA-A receptorSelective agonist binding distinct from the benzodiazepine site
Broad recombinant GABA-A receptor subtypesConcentration-dependent potentiation across alpha and beta subunit combinations
Kappa-opioid receptor (KOR)selective antagonist
Dynorphin / KOR stress systemblocks
Mesolimbic dopamine (nucleus accumbens)disinhibits (indirect)
Mu-opioid receptorweak antagonist (~30x less than KOR)
checking Zuranolone and Aticaprant: at least one combination is flagged to avoid (1 to avoid). treat the red pairs as a reason to reconsider mixing.
two strong CNS depressants (opioid, benzodiazepine, z-drug, barbiturate, gabapentinoid, GABAergic or alcohol) add together on sedation and breathing; a leading cause of fatal respiratory depression.
General educational info, not medical advice.