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for educational and safety purposes
class, effects, and the receptor fingerprint, side by side; add up to four, then source the whole stack
Popular head-to-heads →Mu-opioid receptor (MOR)agonist
Kappa-opioid receptor (KOR)agonist
Delta-opioid receptor (DOR)agonist
Mu-opioid receptor (via oxymorphone metabolite)agonist
Mu-opioid receptor (via noroxycodone metabolite)partial agonist
Mu-opioid receptor (MOR)agonist
CYP2D6 (liver enzyme)substrate (bioactivation)
CYP3A4 (liver enzyme)substrate (metabolism)
Medullary cough centersuppresses
Kappa-opioid receptor (KOR)weak agonist
Delta-opioid receptor (DOR)weak agonist
checking Oxycodone and Hydrocodone: at least one combination is flagged to avoid (1 to avoid). treat the red pairs as a reason to reconsider mixing.
two strong CNS depressants (opioid, benzodiazepine, z-drug, barbiturate, gabapentinoid, GABAergic or alcohol) add together on sedation and breathing; a leading cause of fatal respiratory depression.
General educational info, not medical advice.