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for educational and safety purposes
class, effects, and the receptor fingerprint, side by side; add up to four, then source the whole stack
Popular head-to-heads →Mu-opioid receptor (direct)weak agonist (prodrug)
CYP2D6 (liver enzyme)substrate, bioactivated to morphine
Mu-opioid receptor (via morphine metabolite)potent agonist
Medullary cough centerdepresses cough reflex
Gut mu-opioid receptorsagonist
Delta and kappa opioid receptorsweak agonist
Mu-opioid receptor (parent tramadol)partial agonist
Mu-opioid receptor (via O-desmethyltramadol, M1)agonist
Serotonin transporter (SERT)inhibits reuptake
Norepinephrine transporter (NET)inhibits reuptake
CYP2D6 (metabolizing enzyme)substrate
checking Codeine and Tramadol: at least one combination is flagged to avoid (1 to avoid). treat the red pairs as a reason to reconsider mixing.
two strong CNS depressants (opioid, benzodiazepine, z-drug, barbiturate, gabapentinoid, GABAergic or alcohol) add together on sedation and breathing; a leading cause of fatal respiratory depression.
General educational info, not medical advice.