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compare compounds

class, effects, and the receptor fingerprint, side by side; add up to four, then source the whole stack

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reading the marksactivatesblocks / inhibitsmodulates

81Opi

Buprenorphine

Opioid

effects: Mu-opioid receptor, Pain
suppliers: reference only

Receptor fingerprint

Mu-opioid receptor (MOR)partial agonist

strongKi ~0.4 nM

Kappa-opioid receptor (KOR)antagonist

strongKi ~0.1 nM

Delta-opioid receptor (DOR)antagonist

moderateKi ~4 nM

Nociceptin/ORL1 (NOP) receptorpartial agonist

weakKi ~77 nM

Mu-opioid receptor (slow dissociation)blocks

strongKi ~0.4 nM

81Opi

Methadone

OpioidNMDA Modulator

effects: Mu-opioid receptor, NMDA receptor, Pain
suppliers: reference only

Receptor fingerprint

Mu-opioid receptoragonist

strongIC50 ~4.1 nM

NMDA receptorantagonist

weak

Serotonin transporter (SERT)inhibits reuptake

weak

Norepinephrine transporter (NET)inhibits reuptake

weak

hERG (Kv11.1) potassium channelblocks

moderateIC50 ~9772 nM

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stack compatibility

OverallAvoid

checking Buprenorphine and Methadone: at least one combination is flagged to avoid (1 to avoid). treat the red pairs as a reason to reconsider mixing.

Buprenorphine + Methadone
Avoid
two strong CNS depressants (opioid, benzodiazepine, z-drug, barbiturate, gabapentinoid, GABAergic or alcohol) add together on sedation and breathing; a leading cause of fatal respiratory depression.

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General educational info, not medical advice.